RosettaCON2015
July 29th - August 1st 2015, Leavenworth, WA

Day 1: Wednesday, July 29th

8:45 AM Van departures from UW dorms
9:15 AM Van departures from UW South Center
12.00-2:00 PM Lunch at Kingfisher
2:00-3:50 PM Session 1: Chair: Frank DiMaio (Chapel)
4:00-5:30 PM Free Time
5:30-7:00 PM Dinner at Kingfisher
7:00-8:00 PM Keynote Speaker: David Baker (Chapel).
8:15 PM Poster session 1 (Quail and Tadpole)
9:45 PM Carcassonne match 1 (Kingfisher Patio)

Day 2: Thursday, July 30th

7:30-9:00 AM Breakfast at Kingfisher
9:00-10:20 AM Session 2: Chair: Justin Siegel (Chapel)
10:20-10:40 AM Coffee break
10:40-12:00 PM Session 3 (parallel session: Chapel & Woodpecker)
12:00-2:00 PM Lunch at Kingfisher
2:00-3:00 PM Session 4: Chair: Andrew Leaver-Fay (Chapel)
3:00-3:20 PM Coffee Break
3:20-4:10 PM Discussion Panel 1: Interfaces for Education, Experts, and Everyone. (Chapel)
4:10-4:30 PM Coffee Break
4:30-5:30 PM Session 5: Chair: Brian Kuhlmann (Chapel)
5:30-7:00 PM Dinner at Kingfisher
7:00-8:20 PM Session 6: Chair: Justin Siegel (Chapel)
8:20 PM Poster session 2 (Quail and Tadpole)
9.50 PM Carcassonne match 2 (Kingfisher Patio)

Day 3: Friday, July 31st

7:30-9:00 AM Breakfast at Kingfisher
9:00-10:20 AM Session 7: Chair: Jim Havranek (Chapel)
10:20-10:40 AM Coffee break
10:40-12:00 PM Open Discussion Topic Groups
12:00-2:00 PM Lunch at Kingfisher
2:00-2:50 PM Benchmark and Scorefunction Discussion (Chapel)
2:50-3:20 PM Annual RosettaCON Photo and Coffee break
3:20-4:20 PM Session 8 (parallel session: Chapel & Woodpecker
4:20-4:40 PM Coffee break
4:40-5:20 PM Closing Session (Chapel)
6:00-8:00 PM Dinner at Kingfisher
8:00 PM PI Meeting 2 (Fire Pit by the creek) and Rosetta Intro (Chapel)
10:00 PM Carcassonne Meeting 3 (Kingfisher Patio)

Day 4: Saturday, Aug 1st

7:30-9:00 AM Breakfast at Kingfisher
9:00 AM Bag lunch, checkout, and van/hike departures

A special thanks to our sponsors:

Day 1: Wednesday, July 29th

8:45 AM Van Departures from UW Dorms

9:15 AM Van Departures from UW South Center

12:00-2:00 PM Lunch at Kingfisher

2:00-3:50 PM Session 1: Chair: Frank DiMaio (Chapel)

2:00-2:20 PM Introduction and Welcome
2:20-2:30 PM RosettaCON Code of Conduct (Karen Khar, Kansas University)
2:30-2:40 PM RosettaCommons Annual Report (Dennis Hanson)
2:40-3:10 PM RosettaCON Sponsors: Gene Art, Transcriptic, Silicon Mechanics
3:10-3:30 PM Jacob Bale - Accurate Design of Multi-component Icosahedral Protein Nanocages -
3.30-3:50 PM Amanda Loshbaugh (Kortemme Lab, UCSF) - Engineering Protein Tools That Detect and Respond to Signals in Living Cells -

4:00-5:30 PM Free Time and PI Meeting 1 (Woodpecker)

5:30-7:00 PM Dinner at Kingfisher

5:30-7:00 PM Industry Attendee Meet & Greet at Dinner (Kingfisher)
5:30-7:00 PM jd3 Discussion at Dinner (at far side of indoor dining area)

7:00-8:00 PM Keynote Speaker: David Baker (Chapel)

8:15 PM Poster session 1 (Quail and Tadpole) Last name beginning with "A" through "k" and people attending the first day only.

9:45 PM Carcassonne match 1 (Kingfisher Patio)

Day 2: Thursday, July 30th

7:30-9:00 AM Breakfast at Kingfisher

9:00-10:20 AM Session 2: Chair: Justin Siegel (Chapel)

9:00-10:00 AM Invited Talk 1: Gael McGill -Molecular Visualization: What Does Hollywood Have To Offer?-

10:20-10:40 AM Coffee break 10:40-12:00 PM Session 3 (parallel session:Chapel & Woodpecker)

Chapel: Chair: Bruno Correira

10:40-11:00 AM Terrence OBrien (Siegel Lab, UC Davis) - A Computational Model of a Terpene Cyclase for Mechanistic Understanding -
11:00-11:20 AM Rocco Moretti and Steven Combs (Meiler Lab, Vanderbilt U.) - RosettaDrugDesign - Small Molecule Design Using Rosetta -
11:20-11:40 AM Florian Richter (HU Berlin) - A High-activity uAA-tRNA Synthetase from a Rosetta-designed Library -
11:40-12:00 PM Joseph Jardine (Schief lab, Scripps) - Development of Germline-Targeting Immunogens -

Woodpecker: Chair: Ingemar Andre

10:40-11:00 AM Christopher Bahl (Baker Lab, UW) - De Novo Design of Disulfide-rich Miniproteins: Versatile Scaffolds for High-throughput Engineering -
11:00-11:20 AM Aliza Rubenstein (Khare Lab, Rutgers) - A Mean-field Approach to Preducting Multispecificity -
11:20-11:40 AM Tina Perica (Kortemme Lab, UCSF) - Multi-state Design and in Vivo Protein Interaction Network Edge Perturbations -
11:40-12:00 PM Caitlin Kowalsky (Whitehead Lab, Michigan State University) - Rapid Comprehensive Conformational Epitope Mapping for Antibody-Antigen Structure Prediction -

12:00-2:00 PM Lunch at Kingfisher

Mentoring Table: Women in Rosetta/Science (Mentors: Tanja Kortemme, Deanne Sammond, and Una Natterman)

2:00-3:00 PM Session 4: Chair: Andrew Leaver-Fay (Chapel)

2:00-2:20 PM Lin Jiang (UCLA) - What Can Computational Structural Biology Tell Us About Protein Aggregation in Disease? -
2:20-2:40 PM Karen Khar (Karanicolas Lab, Kensas University) - Rescue of Cancer-associated Mutations of p53 Using Rosetta - Best Talk Award Winner
2:40-3:00 PM Jorge Fallas (Baker Lab, UW) - Design of De Novo Self-assembling Protein Homooligomers -

3:00-3:20 PM Coffee Break

3:30-5:30 PM Discussion Panel 1: Interfaces for Education, Experts, and Everyone (Chapel)

4:10-4:30 PM Coffee Break

4:30-5:30 PM Session 5: Chair: Brian Kuhlman (Chapel)

4:30-4:50 PM Alex Zanghellini (Arzeda) - Enzyme/Strain Design -
4:50-5:10 PM Frank DiMaio (UW) - Energy Function Optimization Guided by Experimental Data -
5:10-5:30 PM Richard Bonneau (NYU) - Peptidomimetic Design -

5:30-7:00 PM Dinner at Kingfisher

6:15 PM Meeting for students/PIs attending the Grace Hopper Conference

7:00-8:00 PM Session 6: Chair: Justin Siegel (Chapel)

7:00-7:20 PM Sergey Ovchinnikov (Baker lab, UW) - Using Co-evolution to Predict Unkown Protein Families and Complexes -
7:20-8:20 PM Invited Talk 2: Lillian Chong - Molecular Simulation of Protein Binding Pathways with Rigorous Kinetics -

8:20 PM Poster session 2 (Quail and Tadpole) Last name beginning with "L" through "Z" and people attending the second half of the conference only.

9:50 PM Carcassonne match 2 (Kingfisher Patio)

Day 3: Friday, July 31st

7:30-9:00 AM Breakfast at Kingfisher

9:00-10:20 AM Session 7: Chair: Jim Havranek (Chapel)

9:00-10:00 AM Invited Talk3: Roberto Chica
10:00-10:20 AM Jason Labonte (Gray Lab, JHU) - RosettaCarbohydrates: Expnding the Computational Tools Available to Glycoscientists - Best Talk Award Winner

10:20-12:00 PM Open Discussion Topic Groups

Conformational and Experimentally Guided Protein Modeling (Green Room Chapel)
Energy Functions (Dipper)
Protein Nucleid Acids (Flicker)
Membrane Proteins (Nuthatch)
Protein Small Molecules (Grotto Pub)
Peptidomimetrics and Non-canonical Amio Acids (Salmon Gallery Terrace)
Antobodies Modeling/Designing (Kingfisher Terrace)
Protein Assemblies and Protein-based Materials (Qual Porch)
Protein-Protein Interactions (Palybarn)

12:00-2:00 PM Lunch at Kingfisher

1:00 PM Interns, intern mentors, intern PIs, and NSF PO to meet for post-program discussion and evaluation

2:00-2:50 PM Benchmark and Scorefunction Discussion (Chapel)

2:00-2:15 PM Sergey Lyskov - Benchmark 2
2:15-2:50 PM Discussion Panel 2: History and Future of the Energy Function

2:50-3:20 PM Annual RosettaCON photo and Coffee Break

3:20-4:20 PM Session 8 (parallel session: Chapel & Woodpecker)

Chapel: Chair: Firas Khatib

3:20-3:40 PM Enrique Marcos - De Novo Design of Protein Folds with Curved Beta-Sheets Suited for Small-molecule Binding -
3:40-4:00 PM Jared Adolf-Bryfogle - A Generalized Framework for Computational Antibody Design -
4:00-4:20 PM Charlie E.M. Strauss - Transcription Factors, Library Screens, and Genetically Encoded Materials -

Woodpecker: Chair: Firas Khatib

3:20-3:40 PM Cyrus Biotechnology - Enterprise Rosetta on the Cloud -
3:40-4:00 PM Brian Kuhlman - Improved detection of Buried Polar Groups -
4:00-4:20 PM Christian Schenkelberg - InteractiveROSETTA: A Graphical User-Interface for Rosetta, Prof. Christoph Bystroff Best Talk Award Winner -

4:20-4:40 PM Coffee Break

4:40-5:20 PM Closing Session (Chapel)

4:40-5:00 PM Gabriel Rocklin - High Throughput Protein Design at the Edge of Folding Best Talk Award Winner
5:00-5:20 PM Awards and Closing Remarks

6:00-8:00 PM Dinner at Kingfisher

8:00 PM PI Meeting 2 (Fire Pit by the Creek) and Rosetta Intro (Chapel)

Intro to Rosetta Development, or Rosetta is a Cheeseburger (Chapel): Cheeseburger Tutorial, FloppyTail Tutorial, MajorIdeas Tutorial.

10:00 PM Carcassonne match 3 (Kingfisher Patio)

Day 4: Saturday, August 1st

7:30-9:00 AM Breakfast at Kingfisher
9:00 AM Bag lunch, checkout, and van/hike departures


	The Rosetta Design Group thanks all Participants, the RosettaCommons Community, the University of Washington, and the Sleeping Lady Mountain Retreat for making this event possible.

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About the Rosetta Design Group The Rosetta Design Group LLC was established in 2007 to bridge the gap between the RosettaCommons academic community and industry.


Contract R&D in modeling and bioinformatics The Rosetta Design Group provides services ranging from assistance for computational scientists in protocol development to fully out-sourced R&D in structural modeing and bioinformatics for computational and experimental groups whose demands exceed their in-house capacities.


Rosetta Design Group Website: http://www.rosettadesigngroup.com ROSETTA resources, events, jobs, the Macromolecular Modeling Blog™, and more.

Industry Participants


Yin He Dorothy Louise Bailey Peter Lee Marie Lee Transcript	Geoffrey Cassell Thermo Fisher Scientific	Curran Parker Art Mann Silicon Mechanics

Aysegul Ozen Genentech	Benjamin Borgo Agilent	Greg Lakatos Zymeworks

Alexandre Zanghellini Arzeda	Lucas Nivon Javier Castellanos Cyrus	Shaun Lippow Bayer

David Nannemann EMD Serono	Juan Velasquez Procter and Gamble	Michael Dolan MSC

Thomas Holberg Blicher Novozymes	Krishna Bajjuri Sutro Biopharma	James Apgar Pfizer

Cara Tracewell Genomatica	Sally O'Connor NSF

Academic Participants

RosettaCommons