Empower your scientific breakthroughs in protein research

Rosetta Design Group offers tailored contract R&D in computational macromolecular modeling, design, and engineering.

From enzymes to antibodies, utilize our protein modeling and engineering expertise to advance your research mission and catalyze breakthroughs.

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Overcome your protein modeling challenges

At Rosetta Design Group, we understand the hurdles you face in computational protein modeling—whether it's a skill gap or a time crunch. Dedicated to the support of scientists and researchers like you, we strive not just to meet but to exceed your research goals.

Accelerate your pipeline

Let us handle the complexity of protein modeling for you.
From de novo design to redesign, our dedicated team has the expertise to take on the heavy lifting
and free up your time to focus on what matters most – your research goals.

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Enhance your capabilities

Already an expert computational biologist or bioinformaticist but struggling with the complexities of the software?
Benefit from our expert guidance and support services or gain access to specialized protein modeling and engineering skills through custom training.

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Empower your research

Partner with us to propel your projects beyond the ordinary and gain access to more than just the forefront of protein
modeling and design; you unlock a suite of benefits tailored to elevate your research and development initiatives:

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Custom solutions

With decades of expertise in protein modeling, our scientists know the right solution for your protein design needs, whether it’s the Rosetta Suite or cutting-edge deep learning models.

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Hourly Consulting

Looking to implement a long-term protein design strategy or still defining the boundaries of a protein design campaign? Rosetta Design Group will help you move forward.

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Software Support Services

Protein design software is fraught with edge cases and cryptic errors. With dedicated software support, turn days of frustration into solutions that move you forward.

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Our Many Areas of Expertise

PROTEIN MODELING & BIOINFORMATICS
PROTEIN DESIGN AND STABILIZATION
HYBRID METHODS MODELING
PROTEIN-PROTEIN INTERFACE DESIGN
ENZYME DESIGN
ANTIBODY AFFINITY MATURATION
ANTIBODY MODELING & ENGINEERING
LIGAND DOCKING
ANTIBODY DEVELOPABILITY
PEPTIDE-PROTEIN INTERACTIONS
SMALL MOLECULE BINDER DESIGN
PEPTIDE DESIGN
PEPTIDO-MIMETICS
AND MORE…

Broad Experience in Many Spaces

Rosetta Design Group has decades of experience in modeling macromolecular systems. From systems that include “just” amino acids to those that are glycosylated, phosphorylated, bind a ligand, contain a nucleic acid, non-canonical amino acid, or peptoid, we have done it and know the tricks.

We have many specific areas of expertise, but our deep experience enables quick growth into new spaces. Work with us to enable your research - contact us today!

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Who we are

Rosetta Design Group specializes in computational protein modeling and design, leveraging the power of molecular modeling tools, such as the Rosetta Suite and modern AI/ML methods.

Originating from the collaborative environment of the Rosetta Commons, Rosetta Design Group brings top-tier protein engineering solutions to industry applications.

We prioritize your research goals, offering the freedom of IP ownership and eliminating IP reach-through concerns.

And, Rosetta Design Group is a member institution of the Rosetta Commons, the eminent protein design community.

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Trusted By

“

Rosetta Design Group listened to my goals for the project, designed an approach to meet my needs, and went beyond what was asked, delivering great value with their insightful custom work. Their scientists have years of experience in the protein design field and can be trusted to deliver the highest quality.

Vanita D. Sood
SVP, Head of Drug Discovery Research
Fable Therapeutics

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Why Choose Us

Leading companies and research institutions trust Rosetta Design Group for their protein design and modeling needs. Our collaboration with top-tier partners reflects our commitment to excellence and innovation in computational macromolecular modeling.

Fee-for-Service Excellence

Rosetta Design Group specializes in fee‑for‑service protein design, ensuring you receive dedicated, focused expertise without the complexity of long‑term royalties.

Transparent collaboration

Enjoy peace of mind with full intellectual property rights to deliverables. Rosetta Design Group assigns all IP for designed sequences.

Deep Community Ties

Rosetta Design Group is an integral part of the Rosetta Commons and stands at the forefront of the protein design community. Our involvement ensures access to cutting-edge developments and collaborative opportunities.

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Ready to start work?

Even if you have a protein modeling or design application not listed here, with our many years of expertise, we can do it!

Resources

Macromolecular Modeling Training

We offer custom training in macromolecular modeling, with a focus on industry licensees of the Rosetta Software Suite and an option for on-site delivery. Training consists of a mix of instructional presentations and hands-on tutorials. Content is custom-tailored. Contact us to explore options for custom, in-house training.

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Attend a RosettaCon

European RosettaCon - Nov. 11-13, 2024
Copenhagen, Denmark

Winter RosettaCon - February 24-28, 2025
Kendall Square, Cambridge, MA, USA

Summer RosettaCon - August 4-8, 2025
Cascadia Mountains, outside Seattle, WA, USA

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Learn more about the Rosetta Commons

The Rosetta Commons consortium comprises international researchers from universities, government labs, and the Rosetta Design Group. The consortium aims to further the research and development of algorithms for macromolecular modeling and design, including the Rosetta Software Suite.

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Download the Rosetta Software Suite

Download the Rosetta Software Suite from the University of Washington's CoMotion. Contact us for inquiries about commercial support services, custom training, or customized development of protein modeling software (like customization or enhancement of Rosetta functionality).

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