Feb
22
2017
0

Only TWO spots left for RosettaCON2017!

RosettaCON2017_edit_slide

There are only TWO spots remaining for RosettaCON2017 for members of the pharmaceutical, biotech, and related industries. Request an invitation through the RosettaCON website.

RosettaCON2017 dates: August 8 – August 11, 2017.

RosettaCON is an annual conference at the Sleeping Lady Mountain Retreat in Washington’s Cascade Mountains, where Rosetta Commons member laboratories share the latest experimental and computational research breakthroughs in protein and macromolecular engineering and structure prediction . The Commons grew out of David Baker’s laboratory at the University of Washington and is now a consortium of over forty international laboratories. Rich Bonneau of New York University, Charlie Strauss of the Los Alamos National Laboratory, Bruno Correia of EPFL of Lausanne, and Vladimir Yarov-Yarovoy of the University of California at Davis organize this year’s conference. We are delighted to have Ian Wilson of The Scripps Research Institute, and Shoshana Wodak of the Vlaamse Institute of Technology (VIB) and the Vrije Universiteit Brussels (VUB) as confirmed guest speakers.

This year’s conference will be featured in a special addition of PLoS. All attendees are invited to contribute to the special edition.

In addition to showcasing cutting edge research, there will be an industry-focused session for fostering collaborations and exploring the exchange of ideas, people and resources. We invite you to participate in this session through presentations, flip charts, and breakout discussions. We hope to expand on the ever-growing number of industry-Rosetta Commons collaborations.

Apr
08
2015
1

Request an invitation to RosettaCON2015

Requests are now being accepted through the RosettaCON website for invitations for the limited openings for RosettaCON2015 for members of the pharmaceutical, biotech, and related industries.

RosettaCon is an invitation-only conference at the Sleeping Lady Mountain Retreat in Washington’s Cascade Mountains, where Rosetta Commons member laboratories share the latest experimental and computational research breakthroughs in protein and macromolecular engineering and structure prediction. The Commons grew out of David Baker’s laboratory at the University of Washington and is now a consortium of twenty-four international laboratories. Justin Siegel of the University of California at Davis and Frank DiMaio of the University of Washington organize this year’s conference. We are delighted to have Bill DeGrado of the University of California at San Francisco, Roberto Chica of the University of Ottowa, Lillian Chong of the University of Pittsburgh, and Gaël McGill of Digizyme and Harvard Medical School as confirmed invited guest speakers.

In addition to showcasing cutting edge research, there will be an industry-focused session for fostering collaborations and exploring the exchange of ideas, people and resources. We invite you to participate in this session through presentations, flip charts, and breakout discussions. We hope to expand on the growing number of industry-Rosetta Commons collaborations, such as:

  • Jeffrey Gray lab – AxioMx collaboration deciphering the specificity of antibodies binding phosporylated peptides
  • Jens Meiler lab – Eli Lilly collaboration developing methods for drug design
  • Tanja Kortemme lab –DSM collaboration developing ROSETTA applications to re-design enzyme substrate specificity

Hands-on Rosetta tutorial sessions may be offered for industry attendees interested in learning to use ROSETTA.

After the conference, hikes, climbs, and backing trips are organized by conference attendees on the most scenic trails and stellar climbs in all of Washington State.

 

Jun
25
2012
1
Jan
17
2010
0

CAPRI: Selected Talks II

This is the third post in the CAPRI series, summarizing the presentations of Jeffrey Gray, Zhiping Weng, and Miriam Eisenstein, as provided by the speakers. More to appear in the continuation of the series.
(more…)

Nov
09
2009
0

PyRosetta

PyRosetta Book

PyRosetta Book

The Gray Lab at Johns Hopkins University has just released PyRosetta, a Python-based interactive platform for accessing the objects and algorithms within the Rosetta protein structure prediction suite.

In addition to the code, the Gray Lab has put together a book that leads the reader through basics of protein structure and energetics to applications in folding, refinement, docking and design. The focus is on enabling users to write custom scripts, so it includes material on Rosetta fundamentals and the appendices have a list of PyRosetta commands and a breakdown of the input files. The book was beta-tested by students during a course at JHU. The course is a series of workshops that teach how to measure and manipulate protein conformations, calculate energies in low- and high-resolution representations, fold proteins from sequence, model variable regions of proteins (loops), dock proteins or small molecules, design protein sequences, and build custom protocols for operations tailored to particular biomolecular applications

The book can be purchased through Lulu:

http://www.lulu.com/content/paperback-book/the-pyrosetta-interactive-platform-for-protein-structure-prediciton-and-design-a-set-of-educational-modules/7187010

or downloaded for free as pdf chapters from http://www.pyrosetta.org under the Tutorial link.

May
20
2009
4

Pfizer using RosettaDock on the Amazon Cloud

In a post yesterday on the Bleeding Edge Biotech Blog, Adam Kraut gives an expanded version of his article for Bio-IT World entitled Antibody Docking on the Amazon Cloud describing how Pfizer is leveraging the power and flexibility of cloud computing to run antibody docking simulations using Rosetta. Pfizer with help from the Rosetta Design Group (that’s us) developed an antibody modeling and docking workflow, which they then scaled up and tested on the cloud with help from BioTeam (which Kraut consults for and talks about in his post). This is a fascinating article and certainly the Pfizer/RDG/BioTeam/Rosetta/Amazon synergy is a phenomenon on the bleeding edge.

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