SCOPE correspondent Suzanne Jacobs writes about the Baker lab’s Computational design of ligand-binding proteins with high affinity and selectivity in Scopeweb | Calculating the Ties that Bind Molecules.
The following reviews provide additional background:
- Emerging themes in the computational design of novel enzymes and protein-protein interfaces.
- An accurate binding interaction model in de novo computational protein design of interactions: If you build it, they will bind.
- Computational design of protein-ligand interfaces: potential in therapeutic development.