Jul
12
2010
0

Postdoctoral fellow – Biotherapeutics @ Pfizer Inc.

A postdoctoral researcher is sought to conduct fundamental computational research to understand molecular origins of aggregation in protein therapeutics, especially monoclonal antibodies and antibody based therapeutics. The research shall involve an inter-disciplinary mix of statistical analyses, bioinformatics, high performance grid computing, molecular biophysics, molecular modeling, and simulation techniques to advance our understanding of protein structure-function-aggregation relationships and mechanism(s) of aggregation. The researcher shall be expected to develop novel approaches to detect aggregation prone regions and three dimensional aggregation prone motifs and suggest ways to improve manufacturability of biotherapeutics via rational design.

For detailed job focus, responsibilities and qualifications, please access http://www.pfizer.com/careers and use code 941315.

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Mar
27
2009
18

Bi-weekly Digest 27/03/09

 In this Bi-weekly digest a novel O2 transport protein designed from first principals (on which we’ll elaborate in an upcoming post – stay tuned) and a nice over-representation of Bioinformatics papres. 

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Feb
22
2009
0

Bi-Weekly Digest 22/02/09

In this Bi-weekly digest, a large scale structural analysis of the human tyrosine phosphatome, a Fas-death domain complex structure, and at least two works concerning calmodulin… 

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Jan
08
2009
0

Bi-Weekly Digest 08/01/09

In a first digest of 2009: two new Rosetta protocols – A new RosettaLigand – docking with full ligand and receptor flexibility, and an improved design protocol to recover native protein-protein interface sequences. Also a new structure of the NaK channel and analysis of its selectivity.

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Nov
27
2008
0

Bi-Weekly Digest 27/11/08

In this Bi-weekly digest, a structural insight into the inhibition mechanism of calpastatins, analysis of core hydrophobic amino acids interactions and more relevant titles form current issues of molecular and computational biology literature. If you want to initiate in a public discussion on one of these, let us know in the comments.

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Nov
08
2008
0

Bi-Weekly Digest 08/11/08

In this Bi-Weekly digest – relevant titles form current issues of molecular and computational biology literature, amongst featured titles: Surface Sites for Engineering Allosteric Control in Proteins and The RNA Polymerase ”Switch Region” Is a Target for Inhibitors. If you want to initiate in a public discussion on one of these, let us know in the comments.

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Oct
12
2008
0

Weekly Digest 12/10/08

In this weekly digest – relevant titles form current issues of Nature Structural and Molecular Biology, Bioinformatics, BMC Bioinformatics, Plos Computational Biology and Journal of Computational Biology. If you want to initiate in a public discussion on one of these, let us know in the comments.

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