Macromolecular Modeling Blog ™

In a research published at Cell, Skerker et al. performs a computational co-variation analysis on a dataset of two-component system sequences. This results in a set of putative specificity determining residues. The authors then demonstrate how they can successfully use these to modulate Histidine Kinase-Response Regulator interactions both in-vitro and in-vivo. By Nir London
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Welcome to the Macromolecular Modeling Blog. We opened this blog in order to provide the modeling community with a helpful resource. Keep updated with what’s new in the modeling world, read executive summaries of the latest literature and stay in touch with pears. We hope this blog would be useful to you as it is fun to us.