Jun
19
2012
2

Direct and selective small molecule activation of BAX

A virtual docking screen discovers a small molecule activator of the pro-apoptotic protein BAX. This novel approach could lead to a ‘new generation’ of apoptotic modulators that directly activate BCL-2 killer proteins. Moreover – it’s cool!

(more…)

Apr
26
2012
0

Weekly literature review

A selection of this week’s interesting papers, brought to you via the Furman Lab

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Written by admin in: Literature Reviews,Title Madness |
Apr
16
2012
0

Weekly literature review

A selection of this week’s interesting papers, brought to you via the Furman Lab

(more…)

Apr
05
2012
0

Weekly literature review

A selection of this week’s interesting papers, brought to you via the Furman Lab

(more…)

Written by admin in: Literature Reviews,Title Madness | Tags:
Apr
03
2012
0

Protein–protein interaction inhibitors get into the groove

In a recent ‘News and Analysis’ piece on Nature Reviews Drug Discovery,  Asher Mullard, heralds the advancement in drug discovery efforts against Protein-protein interactions – “the unmined biology gold reserve”.

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Mar
14
2012
0

Tezcan-RDG supramolecular design collab in the news

Stu Borman wrote a nice piece in Chemical & Engineering News (CEN) highlighting a recent paper in Nature Chemistry that presents the work of a collaboration between the Tezcan Lab at UCSD and the Rosetta Design Group. In this work, a monomeric protein was redesigned to become capable of forming metal and pH tunable nano- to micro- scale sheets, tubes, and other assemblies.


Mr. McGuire: I just want to say one word to you. Just one word.

Benjamin: Yes, sir.

Mr. McGuire: Are you listening?

Benjamin: Yes, I am.

Mr. McGuire: Plastics. Proteins.

Benjamin: Exactly how do you mean?

Written by Xavier Ambroggio in: Literature Reviews | Tags: , , , ,
Nov
05
2011
0

A twitter roundup

For those not yet following us (@molmodelblog) on twitter, a roundup of interesting links from the weekend:

Written by admin in: Resources,Title Madness | Tags: ,
Jun
08
2011
1

One Sided De-Novo Computational Design of a Protein-Protein Interaction

In a recent Science paper, Sarel Fleishman et al. report the de-novo computational design of a protein interface to specifically target and tightly bind a surface patch of the flu hemaglutinin protein. We interview Sarel to get the insights from behind the scenes and the outlook for this exciting approach.

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May
26
2011
2

A PLoS ONE Rosetta Collection

Three articles recently published in PLoS ONE are the harbinger of a RosettaCon 2010 PLoS one collection. How do you design a new enzyme from scratch? How do you model peptide binding with almost no prior information? And what puzzles CAN’T Rosetta solve?

(more…)

May
19
2011
87

A more dynamic literature review

Though I like posting them, and some of the readers like sifting through, the literature reviews always struck me as too static, I wanted to have a more nimble system that can allow readers to comment on a specific paper, to ‘like’ specific papers, and to be able to sort the list this way or another. Following the recent post on Annotator, it came to mind that Disqus might indeed be the answer for a few of these problems. So here is a pilot for this approach, let’s see how it goes. All the titles are posted as comments at the bottom, you can comment/ask questions on specific ones, show appreciation by ‘liking’ them, sort by popularity, moreover – you can add all the ones I missed!

Written by Nir London in: Literature Reviews,Title Madness | Tags:

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