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A postdoctoral researcher is sought to conduct fundamental computational research to understand molecular origins of aggregation in protein therapeutics, especially monoclonal antibodies and antibody based therapeutics. The research shall involve an inter-disciplinary mix of statistical analyses, bioinformatics, high performance grid computing, molecular biophysics, molecular modeling, and simulation techniques to advance our understanding of protein structure-function-aggregation relationships and mechanism(s) of aggregation. The researcher shall be expected to develop novel approaches to detect aggregation prone regions and three dimensional aggregation prone motifs and suggest ways to improve manufacturability of biotherapeutics via rational design.
For detailed job focus, responsibilities and qualifications, please access http://www.pfizer.com/careers and use code 941315.
Please submit a resume and cover letter to firstname.lastname@example.org.
Adimab is looking for scientists with experience in computational protein design to join its Computational Biology group. Successful candidates will work on developing novel computational algorithms and software for rational structure-based design and optimization of antibody molecules and libraries. The computational effort will be closely linked to experimental sequence and binding information obtained from Adimab’s validated, high-throughput antibody discovery platform.
• Ph.D. in Biophysics, Biochemistry or related fields
• Previous academic or biotech industry experience in developing and employing protein design and/or docking algorithms and software
• Strong programming experience in C++ , C or Python
• Strong intuitive grasp of protein structure and function
Adimab’s integrated antibody discovery and optimization platform provides unprecedented speed from antigen to purified, full-length human IgGs. Adimab offers fundamental advantages by delivering diverse panels of therapeutically relevant antibodies that meet the most aggressive standards for affinity, epitope coverage, species cross-reactivity and expressability. Adimab enables its partners to rapidly expand their biologics pipelines through a broad spectrum of technology access arrangements.
For more information, visit http://www.adimab.com.
Adimab is located in New Hampshire’s beautiful Upper Connecticut River Valley, just minutes from Dartmouth College, Dartmouth Medical School, the Tuck School of Business, the Thayer School of Engineering, and Dartmouth-Hitchcock Medical Center. Adimab offers individually tailored compensation packages that are comprised of competitive salary, bonus, and equity components in addition to a world class working environment in a newly constructed lab.